Reduce use in winter as humidity will drop with cold or when heat is in use. Set to 60% or below. 45-50% are good settings to use. Set to 30-60% for desired comfort range.Click to see full answer. In this way, what should I set my dehumidifier to in the winter?Reduce use in winter as humidity will drop with cold or when heat is in use. Set to 60% or below. 45-50% are good settings to use. Set to 30-60% for desired comfort range.One may also ask, what is the best setting for a dehumidifier? A dehumidifier is most effective at warmer temperatures and higher relative humidity levels. Relative humidity levels above 60% can cause mold or mildew to grow, resulting in musty smelling air and unhealthy airborne mold spores. The ideal relative humidity level should be somewhere between 30% – 50%. Consequently, do I need to run my dehumidifier in winter? During cold winter months, the air in your home is usually dry, which means a dehumidifier is not necessary. Most dehumidifiers should not be operated in temperatures below 60° F, since the moisture removed from the indoor air can freeze when it condenses on the cooling coils, which can damage the unit.Should a dehumidifier run all the time?With this assumption, you can safely run your dehumidifier for about 12 hours a day. That should (again, depending on your unit) run all the humid air in your space through the system at least once. I usually tell people to run their dehumidifier for 10-12 hours a day, and of course, the more the better.