But there’s a crossover on Friends that might not be a crossover after all — George Clooney’s ER -like appearance on the Friends season one episode “The One With Two Parts: Part 2.” At the time the episode aired in 1995, George Clooney was a big star on NBC’s E.R., playing Dr. Doug Ross.Click to see full answer. Accordingly, what episode was George Clooney on Friends? The One with Two Parts: Part 2 are Noah Wyle and George Clooney friends? No, Friends Did NOT Have An ER Crossover With George Clooney. Friends had a number of guest stars, including George Clooney and Noah Wyle from E.R., but that episode was in no way a crossover. Here’s why. Also to know, did George Clooney guest star on Friends? George Clooney and Noah Wyle Post “E.R.,” George Clooney guest-starred as a dreamy doctor on “Friends” alongside fellow “E.R.” (though much later) cast member Noah Wyle. In the Season 1 two-parter, Monica (Courteney Cox) and Rachel switch identities so Rachel can use Monica’s insurance.What year was George Clooney in friends? 1995